Pubblicazioni e Ricerca Scientifica
Sono autore principale di diverse ricerche scientifiche in ambito ginecologico pubblicate su importanti riviste internazionali peer-review e dal 2016 Editore dell’European Journal of Contraception and Reproductive Health Care, rivista ufficiale della Società Europea di Contraccezione.
Autore di ricerche scientifiche in ambito ginecologico Dott. Giovanni Grandi
Ricercatore per la salute della donna Dott. Giovanni Grandi

The paradigm of norgestimate: a third-generation testosterone-derivative progestin with a peripheral anti-androgenic activity and the lowest risk of venous thromboembolism.

Grandi G, Del Savio MC, Facchinetti F.

Expert Rev Clin Pharmacol. 2021 Jan 26:1-14.

Prophylactic risk-reducing salpingo-oophorectomy in BRCA mutation carriers: what is going on in a region of northern Italy?

Grandi G, Perrone AM, Perrone A, Mandato VD, Comerci G, Sammarini M, Merisio C, Amadori A, Stefanetti M, Martinello R, Facchinetti F, De Iaco P; Brca Emilia-Romagna Gyneco-Oncological (BERGO) Collaborative Group.

Maturitas. 2021 Jan;143:59-64.

Contemporary prescriptions pattern of different dose levonorgestrel-releasing intrauterine systems in an Italian service for family planning.

Grandi G, De Fata R, Varliero F, Del Savio MC, Facchinetti F.

Gynecol Endocrinol. 2020 Dec;36(12):1086-1089.

Postmenopausal hormone therapy in BRCA gene mutation carriers: to whom and which?

Grandi G, Caroli M, Cortesi L, Toss A, Tazzioli G, Facchinetti F.

Expert Opin Drug Saf. 2020 Jul 10:1-6.

The impact of COVID-19 lockdown on admission to gynecological emergency departments: Results from a multicenter Italian study.

Grandi G, Del Savio MC, Caroli M, Capobianco G, Dessole F, Tupponi G, Petrillo M, Succu C, Paoletti AM, Facchinetti F.

Int J Gynaecol Obstet. 2020 Jun 30.

The gendered impact of coronavirus disease (COVID-19): do estrogens play a role?

Grandi G, Facchinetti F, Bitzer J.

Eur J Contracept Reprod Health Care. 2020 Jun;25(3):233-234.

BRCA Detection Rate in an Italian Cohort of Luminal Early-Onset and Triple-Negative Breast Cancer Patients without Family History: When Biology Overcomes Genealogy.

Toss A, Molinaro E, Venturelli M, Domati F, Marcheselli L, Piana S, Barbieri E, Grandi G, Piombino C, Marchi I, Tenedini E, Tagliafico E, Tazzioli G, Cortesi L.

Cancers (Basel). 2020 May 15;12(5):1252.

The Generally Low Sensitivity of CA 125 for FIGO Stage I Ovarian Cancer Diagnosis Increases for Endometrioid Histotype

Grandi G, Perrone AM, Toss A, Vitagliano A, Friso S, Facchinetti F, Cortesi L, Cascinu S, De Iaco P.

Minerva Medica 2020;111:133-140

Estetrol (E4): the new estrogenic component of combined oral contraceptives

Grandi G, Del Savio MC,  da Silva-Filho AL, Facchinetti F

Expert Rev Clin Pharmacol . 2020 Apr 7;1-4.

Surface roughness of different contraceptive vaginal rings: evaluation by scanning electron microscope (SEM)

Grandi G, Timò A, Sammarini M, Del Savio MC, Facchinetti F

Eur J Contracept Reprod Health Care. 2020 Feb;25(1):60-64

Easy tools to screen Italian women suffering from migraine with and without aura in early reproductive age

Grandi G, Imbrogno MG, Cainazzo MM, Pini LA, Baraldi C, Guerzoni S, Nappi RE, Faccinetti F

Eur J Obstet Gynecol Reprod Biol. 2019 Nov;242:63-67.

Combined hormonal contraceptives in BRCA gene mutation carriers: why not?

Grandi G, Sammarini M, Chiara Del Savio M, Toss A, Facchinetti F
Eur J Contracept Reprod Health Care. 2019 Jul 30:1-3

Estradiol in non-oral hormonal contraception: a "long and winding road"

Grandi G, Barra F, Ferrero S, Facchinetti F
Expert Rev Endocrinol Metab. 2019;14(3):153-155

Hereditary ovarian cancers: state of the art

Toss A, Molinaro E, Sammarini M, Del Savio MC, Cortesi L, Facchinetti F, Grandi G
Minerva Med. 2019 May 6

A comprehensive review of hormonal and biological therapies for endometriosis: latest developments

Barra F, Grandi G, Tantari M, Scala C, Facchinetti F, Ferrero S
Expert Opin Biol Ther. 2019 Feb 14:1-18

Short-term effects of metformin and myo-inositol in women with polycystic ovarian syndrome (PCOS): a meta-analysis of randomized clinical trials

Facchinetti F, Orrù B, Grandi G, Unfer V
Gynecol Endocrinol. 2019 Jan 7:1-9

ESC expert statement on the effects on mood of the natural cycle and progestin-only contraceptives

Merki-Feld GS, Apter D, Bartfai G, Grandi G, Haldre K, Lech M, Lertxundi R, Lete I, Lobo Abascal P, Raine S, Roumen F, Serfaty D, Shulman LP, Skouby S, Bitzer J
Eur J Contracept Reprod Health Care. 2017 Jul 21:1-3

Evaluation of Transvaginal Ultrasound plus CA-125 Measurement and Prophylactic Salpingo-Oophorectomy in Women at Different Risk Levels of Ovarian Cancer: The Modena Study Group Cohort Study

Cortesi L, De Matteis E, Toss A, Marchi I, Medici V, Contu G, Xholli A, Grandi G, Cagnacci A, Federico M
Oncology. 2017;93:377-86

The Jellyfish sign: a new sonographic cervical marker to predict maternal morbidity in abnormally invasive placenta previa

Bertucci E, Sileo FG, Grandi G, Fenu V, Cani C, Mancini L, Mataca E, Facchinetti F
Eur J of Ultrasound. 2017; Nov 21

PET/CT guided surgical excision of small abdominal wall metastases in morbidly obese endometrial cancer patients

Papadia A, Nirgianakis K, Gasparri ML, Grandi G, Bolla D, Klaeser B, Mueller MD
Minerva Ginecol. 2017;69:206-207

The impact of reproductive life on breast cancer risk in women with family history or BRCA mutation

Toss A, Grandi G, Cagnacci A, Marcheselli L, Pavesi S, De Matteis E, Razzaboni E, Tomasello C, Cascinu S, Cortesi L
Oncotarget. 2017;8(6):9144-9154

Laparoscopic management of ectopic pregnancies: a comparison between interstitial and "more distal" tubal pregnancies

Nirgianakis K, Papadia A, Grandi G, McKinnon B, Bolla D, Mueller MD
Arch Gynecol Obstet. 2017;295(1):95-101

Association between urinary incontinence and climacteric symptoms in postmenopausal women

Cagnacci A, Palma F, Carbone MM, Grandi G, Xholli A
Menopause. 2017;24:77-84

Inflammation influences steriod hormone receptors targeted by progestins in endometrial stromal cells from women with endometriosis

Grandi G, Mueller MD, Papadia A, Kocbek V, Bersinger NA, Petraglia F, Cagnacci A, McKinnon B
J Reprod Immunol. 2016;117:30-8

Impact of laparoscopic cystectomy of endometriotic and non-endometriotic cysts on ovarian volume, antral follicle count (AFC) and ovarian Doppler velocimetry

Cagnacci A, Bellafronte M, Xholli A, Palma F, Carbone MM, Di Carlo C, Grandi G
Gynecol Endocrinol. 2016;32 :298-301

Does dienogest influence the inflammatory response of endometriotic cells? A systematic review

Grandi G, Mueller M, Bersinger NA, Cagnacci A, Volpe A, McKinnon B
Inflamm Res. 2016;65:183-92

The Association between Endometriomas and Ovarian Cancer: Preventive Effect of Inhibiting Ovulation and Menstruation during Reproductive Life

Grandi G, Toss A, Cortesi L, Botticelli L, Volpe A, Cagnacci A
BioMed Res International. 2015; 2015:751571

Effect of oral contraceptives containing estradiol and nomegestrol acetate or ethinyl-estradiol and chlormadinone acetate on primary dysmenorrhea

Grandi G, Napolitano A, Xholli A, Tirelli A, Di Carlo C, Cagnacci A
Gynecol Endocrinol. 2015; Aug 18:1-5

Pelvic pain and quality of life of women with endometriosis during quadriphasic estradiol valerate/dienogest oral contraceptive: a patient-preference prospective 24-week pilot study

Grandi G, Xholli A, Napolitano A, Palma F, Cagnacci A
Reprod Sci. 2015;22:626-32

Pharmacokinetic evaluation of desogestrel as a female contraceptive

Grandi G, Cagnacci A, Volpe A
Expert Opin Drug Metab Toxicol. 2014;10:1-10

Prevalence of menstrual pain in young women: what is dysmenorrhea?

Grandi G, Ferrari S, Xholli A, Cannoletta M, Palma F, Romani C, Volpe A, Cagnacci A
J Pain Res. 2012;5:169-174

Satisfaction with prophylactic risk-reducing salpingo-oophorectomy in BRCA mutation carriers is very high and little dependent on the participants' characteristics at surgery: a prospective study.

Grandi G, Sammarini M, Cortesi L, Toss A, Botticelli L, Varliero F, Sighinolfi G, Barbieri E, Facchinetti F.

Menopause. 2021 Feb 1;28(3):263-270.

Breast cancer screening of mutation carriers in the era of COVID-19 pandemic.

Toss A, Lambertini M, Punie K, Grandi G, Cortesi L.

Int J Cancer. 2020 Jun 17:10.1002/ijc.33160.

Drospirenone 4 mg-only pill (DOP) in 24+4 regimen: a new option for oral contraception.

Del Savio MC, De Fata R, Facchinetti F, Grandi G.

Expert Rev Clin Pharmacol. 2020 Jul;13(7):685-694.

The reduction of CA 125 serum levels in BRCA 1/2 mutation carriers after risk-reducing salpingo-oophorectomy is only partially associated with surgery: a prospective cohort, other biomarker controlled, study.

Grandi G, Del Savio MC, Sammarini M, Cortesi L, Toss A, Piombino C, Facchinetti F.

Eur J Cancer Prev. 2020 Jul;29(4):350-356.

Primary fallopian tube carcinoma (PFTC) in a BRIP-1 mutation carrier: the first case report.

Grandi G, Caroli M, Alboni C, Cortesi L, Toss A, Barbieri E, Botticelli L, Facchinetti F.

Fam Cancer. 2020 Apr 24

A regional audit system for stillbirth: a way to better understand the phenomenon

Po' G, Monari F, Zanni F, Grandi G, Lupi C, Facchinetti F; Stillbirth Emilia-Romagna Audit Group
BMC Pregnancy Childbirth. 2019;19(1):276

Future directions in endometriosis treatment: discovery and development of novel inhibitors of estrogen biosynthesis

Barra F, Romano A, Grandi G, Facchinetti F, Ferrero S
Expert Opin Investig Drugs. 2019 May 9:1-4

Increasing BMI is associated with both endometrioid and serous histotypes among endometrial rather than ovarian cancers: a case-to-case study

Grandi G, Perrone AM, Chiossi G, Friso S, Toss A, Sammarini M, Facchinetti F, Botticelli L, Palma F, De Iaco P
Gynecol Oncol. 2019;154:163-68

Hormonal contraception in women with endometriosis: a systematic review

Grandi G, Barra F, Ferrero S, Sileo FG, Bertucci E, Napolitano A, Facchinetti F
Eur J Contracept Reprod Health Care. 2019 Jan 21:1-10

Levonorgestrel-releasing intra-uterine systems as female contraceptives

Grandi G, Farulla A, Sileo FG, Facchinetti F
Expert Opin Pharmacother. 2018;19(7):677-686

Estradiol in hormonal contraception: real evolution or just same old wine in a new bottle?

Grandi G, Facchinetti F, Bitzer J
Eur J Contracept Reprod Health Care. 2017;22:245-46

Combined hormonal contraceptives use and the risk of breast cancer in a population of women with a family history

Grandi G, Toss A, Cagnacci A, Marcheselli L, Pavesi S, Facchinetti F, Cascinu, Cortesi L
Clin Breast Cancer. 2018;18:e15-24

The association between progestins, nuclear receptors expression and inflammation in endometrial stromal cells from women with endometriosis

Grandi G, Mueller MD, Bersinger NA, Facchinetti F, McKinnon BD
Gynecol Endocrinol. 2017;17:1-4

Vaginal Alpha-Lipoic Acid shows an anti-inflammatory effect on the cervix, preventing its shortening after primary tocolysis. A pilot, randomized, placebo-controlled study

Grandi G, Pignatti L, Ferrari F, Dante G, Neri I, Facchinetti F
J Matern Fetal Neonatal Med. 2016 Oct 9:1-23

TNFα-induced IKKβ complex activation influences epithelial, but not stromal cell survival in endometriosis

Kocbek V, Grandi G, Blank F, Wotzkow C, Bersinger NA, Mueller MD, Kyo S, McKinnon BD
Mol Hum Reprod. 2016;22(11):768-777

Progestin suppressed inflammation and cell viability of tumor necrosis factor-α stimulated endometriotic stromal cells

Grandi G, Mueller M, Bersinger N, Papadia A, Nirgianakis K, Cagnacci A, McKinnon BD
Am J Reprod Immunol. 2016;76:292-8

Dienogest mediates midkine suppression in endometriosis

Nirgianakis K*, Grandi G*, McKinnon B, Bersinger NA, Cagnacci A, Mueller MD
Hum Reprod. 2016;31:1981-6 (* joint First Authors)

Metabolic impact of combined hormonal contraceptives containing estradiol

Grandi G, Napolitano A, Cagnacci A
Exp Opionion Drug Metab Toxicol. 2016;12:779-87

Hepatic resection during cytoreductive surgery for primary or recurrent epithelial ovarian cancer

Gasparri ML, Grandi G, Bolla D, Gloor B, Imboden S, Panici PB, Mueller MD, Papadia A
J Cancer Res Clin Oncol. 2016;142:1509-20

Body composition and resting metabolic rate of perimenopausal women using continuous progestogen contraception

Napolitano A, Zanin R, Palma F, Romani C, Grandi G, Di Carlo C, Cagnacci A
Eur J Contracept Reprod Health Care. 2015;25:1-8

Hereditary Ovarian Cancer: Not Only BRCA 1 and 2 Genes

Toss A, Tomasello C, Razzaboni E, Contu G, Grandi G, Cagnacci A, Schilder RJ, Cortesi L
Biomed Res Int. 2015;2015:341723. Epub 2015 May 17

Prospective measurement of blood pressure and heart rate over 24 hours in women using combined oral contraceptives with estradiol

Grandi G, Xholli A, Napolitano A, Piacenti I, Bellafronte M, Cagnacci A
Contraception. 2014;90:529-34

Intensity of menstrual pain and estimated angle of uterine flexion

Cagnacci A, Grandi G, Cannoletta M, Xholli A, Piacenti I, Volpe A
Acta Obstet Gynecol Scand. 2014;93:58-63

Modification of body composition and metabolism during oral contraceptives containing non-androgenic progestins in association with estradiol or ethinylesradiol

Grandi G, Piacenti I, Volpe A, Cagnacci A
Gynecol Endocrinol. 2014;30:676-80

Inter-menstrual pelvic pain, quality of life and mood

Grandi G, Xholli A, Ferrari S, Cannoletta M, Volpe A, Cagnacci A
Gynecol Obstet Invest. 2013;75:97-100
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